If one has the money to buy "name brand", that's what I always suggest. If you should ever decide to get rid of the equipment, it's generally easier to sell Gibson, Fender, etc.
I've been playing Gibsons more here lately, but I am a Fender Strat guy for the most part after all these years. It's a versatile instrument. I have always run a 'straight Strat' setup...single coil pickups...no humbuckers. Lots of Strat options out there, though, including the HSS (Hum/Singe/Single) pup configuration. Your best quality with Fenders will be in descending order: American, Japanese, Mexican...and the rest...I own some of each, and they're all fine instruments, but you'll pay more for MIA. Is it worth the price difference over MIJ or MIM? That will depend on the guitar and how it fills your needs.
As far as amps go, (again if you don't mind spending some money) look at one of the Fender re-issues (Princeton, Deluxe, Reverb, Vibrolux, etc.) If you are just going to be playing at home, the Princeton is a nice little amp. They've done a really nice job with the '68 Drip Edge re-issue. I have an original '72 with which to compare.
There are so many gear choices out there to be made. This one proffered today is what I'd do currently. I may feel differently tomorrow!
I am subscribed to this thread, so I know when folks post. If you want to run some ideas by me (and the rest of the guitar-totin' crew...ELC should be chiming in before too long, I'd think), I'd be happy to lend advice as I can.
In the interim, here's a picture of my general gig rig these last couple-three months:
Not sure if the pic is showing here via the web link widget (don't know why, either)...so I've attached it...