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Thread: Covid-19 - Treatments & Vaccines

  1. #181
    Good news from Andy Slavitt today. In other news, it seems like the Bubonic Plague is back. Case in China yesterday.

  2. #182
    Good early results from the Moderna and Pfizer vaccine human studies.

    https://www.statnews.com/2020/07/14/...mune-response/

  3. #183
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    They really need to broaden their recruiting for these trials. It is 89% white for a virus thatís disproportionately impacting Black and Hispanic people albeit for social not biological reasons.

  4. #184
    Quote Originally Posted by PhDeac View Post
    They really need to broaden their recruiting for these trials. It is 89% white for a virus thatís disproportionately impacting Black and Hispanic people albeit for social not biological reasons.
    They specifically mentioned including more minority participants in the next stage of trials.

  5. #185
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    Covid-19 - Treatments & Vaccines

    Quote Originally Posted by DistrictDeacon View Post
    They specifically mentioned including more minority participants in the next stage of trials.
    Right. They need to be doing that in the earliest stages as well. ďLooks good for the white people, now letís try it on everybody elseĒ isnít sufficient.

  6. #186
    Quote Originally Posted by PhDeac View Post
    Right. They need to be doing that in the earliest stages as well. ďLooks good for the white people, now letís try it on everybody elseĒ isnít sufficient.
    Can you tell us why it's not sufficient, using your (undoubtedly vast) personal experience in the different stages of vaccine trials?

  7. #187
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    Quote Originally Posted by DistrictDeacon View Post
    Can you tell us why it's not sufficient, using your (undoubtedly vast) personal experience in the different stages of vaccine trials?
    Seriously? Thereís a long history of science and medicine conducting research primarily on white subjects. The risk is that treatments that may be effective on some people will not be effective on others. Clinical trials need to be more diverse.

    You can google diversity in clinical trials or any other related search prompt.

    District, Iím surprised. Thatís something Angus would post. Youíre better than this.

  8. #188
    Quote Originally Posted by PhDeac View Post
    Seriously? Thereís a long history of science and medicine conducting research primarily on white subjects. The risk is that treatments that may be effective on some people will not be effective on others. Clinical trials need to be more diverse.

    You can google diversity in clinical trials or any other related search prompt.

    District, Iím surprised. Thatís something Angus would post. Youíre better than this.
    Please don't cover up your ignorance with condescending bullshit.

    "It is 89% white for a virus thatís disproportionately impacting Black and Hispanic people albeit for social not biological reasons." -PHDeac, 1 day ago.

    Drug trials have different phases that focus on different things. Phase 1 is to determine safe dosages, which is affected by a person's biology, not by their social situation.

  9. #189
    There are enough variations in human biology that it is wise for even phase 1 to capture as wide a swath of that variation as possible early. A for instance, and this is because it is easy, not because it necessarily is relevant in this particular situation, is the sickle cell trait. Sickle cell trait and disease occurs at a much higher rate in populations of African descent than in populations of European descent. If you want to know whether there is any interaction, it is necessary to have a test group of people who are likely to include that.

    As human beings, we are all more than 99% alike. But it is that less than 1% variation that makes individuals unique. It would behoove anyone testing drugs and biologics like the Corona virus vaccine to try and capture as broad a swath in that variability as possible, given the limits of size on test groups. Some adverse impacts don't even show until the vaccine goes into widespread use. Test on 50,000 subjects may not show rare impacts that become apparent when the vaccine is administered to 300 million people. That is why the Food and Drug Administration administers the "Adverse Reaction" to drugs and biologics program.

    There is a much better chance of finding the adverse events if the test groups are as diverse as possible.

  10. #190

  11. #191
    Astrazeneca vaccine deemed safe and able to produce immune response in initial trial.

    Washington Post story
    about

    Lancet article.
    Last edited by Deaconblue; 07-20-2020 at 10:59 AM.

  12. #192
    Duke Human Vaccine Institute seeing promising results for antibody treatment. An interim measure and something for those who cannot be vaccinated.

    https://today.duke.edu/2020/07/duke-...kly_2020-07-25

  13. #193
    Quote Originally Posted by Deaconblue View Post
    Duke Human Vaccine Institute seeing promising results for antibody treatment. An interim measure and something for those who cannot be vaccinated.

    https://today.duke.edu/2020/07/duke-...kly_2020-07-25
    Fuck duke.
    Birds are real.

  14. #194
    Quote Originally Posted by birdman View Post
    Fuck duke.
    Rare great post.

  15. #195

  16. #196
    people who know things, Fauci talking about a November vaccine

    what does that actually mean?

  17. #197
    Quote Originally Posted by JuiceCrewAllStar View Post
    people who know things, Fauci talking about a November vaccine

    what does that actually mean?
    :link?:

  18. #198
    see the headline from the Guardian live blog: https://www.theguardian.com/us-news/...t-news-updates

    actual post is several entries down

  19. #199
    Quote Originally Posted by JuiceCrewAllStar View Post
    people who know things, Fauci talking about a November vaccine

    what does that actually mean?
    No kidding. Bill Gates, Fauci and a number of other "experts" have also said there will need to be many vaccines, as apparently there are hundreds of mutations (actually one medpress article quoted 6k!) and that one vaccine will hardly protect the masses against the many strains. How many will want to line up to be the first guinea pig to get vaccines when they do come out??? I know many Drs. that would rather not get initial vaccine, but will be required to if they want to continue practicing.

    Hope I'm wrong and a vaccine knocks out most strains, but doesn't sound real promising in short-term the way it is mutating. thankfully the new strains are not more deadly, but unfortunately more virulent which could increase deaths ignoring some of the breakthroughs in medicines to treat patients with it.

  20. #200
    I don't think anything that you just said about strains and mutation rates is correct.

    As far as vaccines by November there will most likely be preliminary data from the current trials being run that enroll 30,000 or so people that point to the safety and efficacy at large levels. It changes nothing about when the vaccine will actually be widely available which will be beginning of 2021 at large scale if successful. Now with almost a week or two before the election the notion there is an effective vaccine available be hyped up and the cornavirus problem cured, almost certainly.

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