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Thread: Covid-19 - Treatments & Vaccines

  1. #21
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    Quote Originally Posted by ConnorEl View Post
    Being among those that will be required to receive the first widely available vaccine...please letís not over rush the damn thing. Appropriately/relatively safe and effective, please.
    You'll probably catch Asperger's from it.

  2. #22
    Quote Originally Posted by WFFaithful View Post
    Does the virus cause permanent lung damage?
    https://www.latimes.com/science/stor...mpression=true

  3. #23
    Banhammer'd
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    A new treatment is being rolled out tomorrow. Everyone should drink four bottles of Trump water and eat at least one Trump steak each day.

  4. #24
    THE quintessential dwarf dartsndeacs's Avatar
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    Man thatís fairly scary
    just drivin' round in John Voight's car

  5. #25
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    Quote Originally Posted by ConnorEl View Post
    A vaccine will be the thing that whips this.

    In the meantime, one potential treatment Iím intrigued by is interleukin (IL)-6 receptor inhibitors for patients with evidence of elevated cytokine response.
    Tocilizumab does seem to help, at least anecdotally. I am involved in setting up a couple of trials to investigate this further. I am an Immunologist who studies acute viral infections, specifically infections which drive potent inflammation and tissue damage/dysfunction as is seen in COVID19.

    Canakinumab is another target gaining interest. It is an Il-1b blocking antibody. During COVID19 pathogenesis it is thought that IL-1 production in the lung drives a dysfunctional immune response, overt and progressive tissue damage and this Il-1 ultimately drives the IL-6 and downstream issues associated with cytokine storm. We are looking at this for treating mild patients before intubation/ICU.

    Biggest issue with either Toci or Cana will be availability. These arenít cheap treatments and stocks are not maintained for general use so supply is limited. Iím trying to get some clinicians to look at Anakinra which also blocks IL-1 signaling as an alternate.

    People are also considering early interferon therapy to counteract the relative lack of interferon and antiviral immunity the virus seems to induce. Iím skeptical that this will be tolerated well in patients at the early stage and I think it might make conditions worse.

    Vaccine will be the gold standard for stopping this from continual spread but time is not on our side. Need to find effective treatments now while we wait.

  6. #26
    Quote Originally Posted by BigTreeDeac View Post
    Tocilizumab does seem to help, at least anecdotally. I am involved in setting up a couple of trials to investigate this further. I am an Immunologist who studies acute viral infections, specifically infections which drive potent inflammation and tissue damage/dysfunction as is seen in COVID19.

    Canakinumab is another target gaining interest. It is an Il-1b blocking antibody. During COVID19 pathogenesis it is thought that IL-1 production in the lung drives a dysfunctional immune response, overt and progressive tissue damage and this Il-1 ultimately drives the IL-6 and downstream issues associated with cytokine storm. We are looking at this for treating mild patients before intubation/ICU.

    Biggest issue with either Toci or Cana will be availability. These arenít cheap treatments and stocks are not maintained for general use so supply is limited. Iím trying to get some clinicians to look at Anakinra which also blocks IL-1 signaling as an alternate.

    People are also considering early interferon therapy to counteract the relative lack of interferon and antiviral immunity the virus seems to induce. Iím skeptical that this will be tolerated well in patients at the early stage and I think it might make conditions worse.

    Vaccine will be the gold standard for stopping this from continual spread but time is not on our side. Need to find effective treatments now while we wait.
    Somebody get Brad to verify this guyís credentials.

  7. #27
    Long form CV and transcripts required to post here

  8. #28
    W2s + dicks
    We're going to be good again.

  9. #29
    Quote Originally Posted by MichDeac25 View Post
    From an article in today's WSJ: "WUHAN, ChinaóChinese doctors who have for months treated coronavirus patients with chloroquine say there is no clear evidence the anti-malarial drug is effective against the deadly pathogen, raising questions about a remedy President Trump has touted as a potential cure."
    Not only that, but it appears chloroquine (severely?) damages the heart in fairly high percentages of patients, according to the French Health Ministry.
    https://www.vox.com/covid-19-coronav...vid-19-studies

  10. #30
    Quote Originally Posted by shogun6066 View Post
    Not only that, but it appears chloroquine (severely?) damages the heart in fairly high percentages of patients, according to the French Health Ministry.
    https://www.vox.com/covid-19-coronav...vid-19-studies
    Considering how long chloroquine has been around, I would have expected medical science to have a better handle on the side effects.

  11. #31
    There is nothing definitive to take from that article and it has an obvious bias. How would we have a better handle on how chloroquine affects people with COVID-19?

  12. #32
    THE quintessential dwarf dartsndeacs's Avatar
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    Quote Originally Posted by MichDeac25 View Post
    From an article in today's WSJ: "WUHAN, ChinaóChinese doctors who have for months treated coronavirus patients with chloroquine say there is no clear evidence the anti-malarial drug is effective against the deadly pathogen, raising questions about a remedy President Trump has touted as a potential cure."
    Read this today which seems to indicate it is effective

    https://docs.google.com/document/d/1...ARUomR9Ww/edit
    just drivin' round in John Voight's car

  13. #33
    Randomized trial published today, no real benefit for HCQ

    https://www.medrxiv.org/content/10.1....10.20060558v1


    o assess the efficacy and safety of hydroxychloroquine (HCQ) plus standard-of-care (SOC) compared with SOC alone in adult patients with COVID-19. Design Multicenter, open-label, randomized controlled trial. Setting 16 government-designated COVID-19 treatment centers in China through 11 to 29 in February 2020. Participants 150 patients hospitalized with COVID-19. 75 patients were assigned to HCQ plus SOC and 75 were assigned to SOC alone (control group). Interventions HCQ was administrated with a loading dose of 1, 200 mg daily for three days followed by a maintained dose of 800 mg daily for the remaining days (total treatment duration: 2 or 3 weeks for mild/moderate or severe patients, respectively). Main outcome measures The primary endpoint was the 28-day negative conversion rate of SARS-CoV-2. The assessed secondary endpoints were negative conversion rate at day 4, 7, 10, 14 or 21, the improvement rate of clinical symptoms within 28-day, normalization of C-reactive protein and blood lymphocyte count within 28-day. Primary and secondary analysis was by intention to treat. Adverse events were assessed in the safety population. Results The overall 28-day negative conversion rate was not different between SOC plus HCQ and SOC group (Kaplan-Meier estimates 85.4% versus 81.3%, P=0.341). Negative conversion rate at day 4, 7, 10, 14 or 21 was also similar between the two groups. No different 28-day symptoms alleviation rate was observed between the two groups.

  14. #34
    Saw an article today that COVID patients are being placed on their stomach to relieve pressure and allow for more air in their lungs.

  15. #35
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    Quote Originally Posted by tiltdeac View Post
    Randomized trial published today, no real benefit for HCQ

    https://www.medrxiv.org/content/10.1....10.20060558v1
    Yea, but were these MDs?

  16. #36
    Quote Originally Posted by bym051d View Post
    Saw an article today that COVID patients are being placed on their stomach to relieve pressure and allow for more air in their lungs.
    It's called proning. This is a good tweetorial on it


  17. #37
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    Like doggie style.

  18. #38

  19. #39
    New French study finding that hydroxychloroquine is not effective for COVID19: "No evidence of clinical efficacy of hydroxychloroquine in patients hospitalised for COVID-19 infection and requiring oxygen: results of a study using routinely collected data to emulate a target trial" https://www.medrxiv.org/content/10.1...699v1.full.pdf

  20. #40
    One interesting and promising development on the vaccine front. Two large drug companies are combining technologies to get a vaccine into testing this summer:

    https://www.statnews.com/2020/04/14/...collaboration/


    The Milken Institute maintains a tracking sheet of development of vaccines and treatment protocols for Covid-19. The link is to a pdf file.

    Milken Institute

    ETA: Updated tracker

    Milken Institute tracker 4-20
    Last edited by Deaconblue; 04-21-2020 at 11:32 AM.

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