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Thread: Covid-19 - Treatments & Vaccines

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  1. #1

    Covid-19 - Treatments & Vaccines

    In this thread we discuss and keep track of the various treatments and vaccines that are being researched, created, and tested related to Covid-19. Here are some articles to get the discussion started:

    https://www.sciencemag.org/news/2020...ew-coronavirus

    https://abcnews.go.com/Health/covid-...ry?id=69881230

    https://www.healthline.com/health-ne...l-trial-stages

    https://www.city-journal.org/coronavirus-vaccine

    https://www.wired.com/story/creator-...wing-covid-19/

    https://www.bloomberg.com/news/artic...er-big-tobacco

  2. #2
    My take:

    - anti-malarials are a joke / fools gold
    - anti-virals *might* work - interested to see the Gilead data from China
    - sounds like the virus is fairly conserved (i.e. doesn't rapidly mutate) so vaccine approach will work - question is whether they can develop / approve something in time. lot of damage will be done by Q1 next year.
    - as with other things, Trump is a total fool and desperate to tout any wingbat potential therapy (see anti-malarials) which will (in the end) cause way more harm than good if rubes anchor on it for no reason
    - the new head of the FDA (Hahn) is a yes man joke - he will do / approve anything that Trump says which is dangerous
    - if you really want to stay informed follow the old head Scott Gottlieb. He has very sober analysis on the situation and good access to data / intel as he hasn't totally detonated Trump (he was a Trump appointee)
    - to summarize, my view is that good antiviral data is the ONLY thing that will take us off the 100k+ death trajectory in US and millions globally (wait til this thing hits the 3rd world). but it's a 1 in 10 longshot IMO
    - looking forward to antivaxxers avoiding the vaccine when it comes. ah, the joy of Darwinism at work....
    Last edited by Henry Chinaski; 04-02-2020 at 07:11 AM.

  3. #3
    THE quintessential dwarf dartsndeacs's Avatar
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    Quote Originally Posted by Henry Chinaski View Post
    My take:

    - as with other things, Trump is a total fool and desperate to tout any wingbat potential therapy (see anti-malarials) which will (in the end) cause way more harm than good if rubes anchor on it for no reason
    Ingraham is all in on Hydrocoxy and had a doctor on that claimed only obese people are dying and ended the segment with breaking news that none of his patients using it had to be intubated. Ended up calling it a breaking news game changer. This was an hour ago.
    just drivin' round in John Voight's car

  4. #4
    Quote Originally Posted by palmab03 View Post
    Ingraham is all in on Hydrocoxy and had a doctor on that claimed only obese people are dying and ended the segment with breaking news that none of his patients using it had to be intubated. Ended up calling it a breaking news game changer. This was an hour ago.
    https://www.nytimes.com/2020/04/01/h...s-malaria.html

    Hope it's true. Unfortunately Ingraham touting it definitely gives me pause.

    Glad I'm jacked, bro.

  5. #5
    Quote Originally Posted by mako1331 View Post
    https://www.nytimes.com/2020/04/01/h...s-malaria.html

    Hope it's true. Unfortunately Ingraham touting it definitely gives me pause.

    Glad I'm jacked, bro.
    Way too early to know. Another study from China was completely negative. Pretty unlikely to be a game changer.

  6. #6
    Quote Originally Posted by tiltdeac View Post
    Way too early to know. Another study from China was completely negative. Pretty unlikely to be a game changer.
    That's not what my President has been telling me. And I'm pretty sure God speaks directly into his ear. And stop trusting the Chinese, commie. They started all this shit.

  7. #7
    Quote Originally Posted by Henry Chinaski View Post
    My take:

    - anti-malarials are a joke / fools gold
    - anti-virals *might* work - interested to see the Gilead data from China
    - sounds like the virus is fairly conserved (i.e. doesn't rapidly mutate) so vaccine approach will work - question is whether they can develop / approve something in time. lot of damage will be done by Q1 next year.
    - as with other things, Trump is a total fool and desperate to tout any wingbat potential therapy (see anti-malarials) which will (in the end) cause way more harm than good if rubes anchor on it for no reason
    - the new head of the FDA (Hahn) is a yes man joke - he will do / approve anything that Trump says which is dangerous
    - if you really want to stay informed follow the old head Scott Gottlieb. He has very sober analysis on the situation and good access to data / intel as he hasn't totally detonated Trump (he was a Trump appointee)
    - to summarize, my view is that good antiviral data is the ONLY thing that will take us off the 100k+ death trajectory in US and millions globally (wait til this thing hits the 3rd world). but it's a 1 in 10 longshot IMO
    - looking forward to antivaxxers avoiding the vaccine when it comes. ah, the joy of Darwinism at work....
    Patting my own back on this one. Still amazing that we got way more fatalities and the 3rd world has been relatively unscathed

  8. #8
    Dickie Hemric
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    A vaccine will be the thing that whips this.

    In the meantime, one potential treatment Iím intrigued by is interleukin (IL)-6 receptor inhibitors for patients with evidence of elevated cytokine response.
    I love mankind...itís people I canít stand!!

  9. #9
    Ricky Peral
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    Quote Originally Posted by ConnorEl View Post
    A vaccine will be the thing that whips this.

    In the meantime, one potential treatment Iím intrigued by is interleukin (IL)-6 receptor inhibitors for patients with evidence of elevated cytokine response.
    Tocilizumab does seem to help, at least anecdotally. I am involved in setting up a couple of trials to investigate this further. I am an Immunologist who studies acute viral infections, specifically infections which drive potent inflammation and tissue damage/dysfunction as is seen in COVID19.

    Canakinumab is another target gaining interest. It is an Il-1b blocking antibody. During COVID19 pathogenesis it is thought that IL-1 production in the lung drives a dysfunctional immune response, overt and progressive tissue damage and this Il-1 ultimately drives the IL-6 and downstream issues associated with cytokine storm. We are looking at this for treating mild patients before intubation/ICU.

    Biggest issue with either Toci or Cana will be availability. These arenít cheap treatments and stocks are not maintained for general use so supply is limited. Iím trying to get some clinicians to look at Anakinra which also blocks IL-1 signaling as an alternate.

    People are also considering early interferon therapy to counteract the relative lack of interferon and antiviral immunity the virus seems to induce. Iím skeptical that this will be tolerated well in patients at the early stage and I think it might make conditions worse.

    Vaccine will be the gold standard for stopping this from continual spread but time is not on our side. Need to find effective treatments now while we wait.

  10. #10
    Quote Originally Posted by BigTreeDeac View Post
    Tocilizumab does seem to help, at least anecdotally. I am involved in setting up a couple of trials to investigate this further. I am an Immunologist who studies acute viral infections, specifically infections which drive potent inflammation and tissue damage/dysfunction as is seen in COVID19.

    Canakinumab is another target gaining interest. It is an Il-1b blocking antibody. During COVID19 pathogenesis it is thought that IL-1 production in the lung drives a dysfunctional immune response, overt and progressive tissue damage and this Il-1 ultimately drives the IL-6 and downstream issues associated with cytokine storm. We are looking at this for treating mild patients before intubation/ICU.

    Biggest issue with either Toci or Cana will be availability. These arenít cheap treatments and stocks are not maintained for general use so supply is limited. Iím trying to get some clinicians to look at Anakinra which also blocks IL-1 signaling as an alternate.

    People are also considering early interferon therapy to counteract the relative lack of interferon and antiviral immunity the virus seems to induce. Iím skeptical that this will be tolerated well in patients at the early stage and I think it might make conditions worse.

    Vaccine will be the gold standard for stopping this from continual spread but time is not on our side. Need to find effective treatments now while we wait.
    Somebody get Brad to verify this guyís credentials.

  11. #11
    posted this on the Pit thread:

    The problem is that all that data being written about comes from studies where they excluded 1) people with severe symptoms of COVID and 2) people with any co-morbidities that might be exacerbated by HCQ.

    Bad news, there are a WHOLE lot of people in that second group.

  12. #12
    Pitt claiming success toward a vaccine


  13. #13
    I posted about the Reynolds sub working on Covid vaccines.

    Here is more info

    https://www.journalnow.com/business/...4c8dad603.html

  14. #14

  15. #15
    THE quintessential dwarf dartsndeacs's Avatar
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    https://www.hindustantimes.com/india...IylXUAhlI.html

    " Consistent with a friendís thesis that serious cases look an awful lot like latent TB kicking into active, including very sudden onset, ground glass X-ray images, etc."

    Coronavirus update- TB vaccine in childhood may offer Covid-19 protection: Researchers
    just drivin' round in John Voight's car

  16. #16
    Does the virus cause permanent lung damage?

  17. #17
    Quote Originally Posted by WFFaithful View Post
    Does the virus cause permanent lung damage?
    Iíd guess itís too early to know.

  18. #18
    Quote Originally Posted by WFFaithful View Post
    Does the virus cause permanent lung damage?
    https://www.latimes.com/science/stor...mpression=true

  19. #19
    THE quintessential dwarf dartsndeacs's Avatar
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    Man thatís fairly scary
    just drivin' round in John Voight's car

  20. #20
    From an article in today's WSJ: "WUHAN, ChinaóChinese doctors who have for months treated coronavirus patients with chloroquine say there is no clear evidence the anti-malarial drug is effective against the deadly pathogen, raising questions about a remedy President Trump has touted as a potential cure."

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