Totally agree on the self-driving cars... That's going to happen, and probably sooner than we think. Will happen in the next 5-10 years w/ 18 wheelers due to driver shortages (nobody wants to be a truck driver anymore and regulations are getting more and more strict). Once that changes, and Tesla comes out with a cheaper car, we'll hit the tipping point quickly. I do think it will mostly be a hybrid-style for a while, though... Kind of like cruise control (use it on the highway, but not in your neighborhood).
Almost everything (including cars) will run on electricity... And that electricity will be largely generated through solar technology. Fossil fuels, at least in the US, will be a thing of the past.
People will have been to Mars. Perhaps a lot of them. Maybe even to live.
I also think there is a relatively significant chance (~1-5%) that humans will be extinct. A number of potential reasons (in order): Singularity, Nuclear Terrorism/Global War, Aliens, Asteroid, Virus.
Along with that, there is a similar chance that AI will cause us to become "immortal", at least in our consciousness.