Using the bracket matrix (103 brackets so a wisdom of the crowds type situation) as a basis, Wake is one of the last four teams in. That means we'd be sent to Dayton if that held. The other teams there would be MTSU, Seton Hall, and Arkansas. Wake would be the favorite against any three of them in Vegas (likely by 3 to 4 points over all three). If Wake won the opener and advanced to play a six seed, those options would be South Carolina, Maryland, Notre Dame, and Xavier. Wake couldn't play ND or Xavier since they met during the season so the options would be Maryland or South Carolina. Wake would open up as a slight favorite over Maryland and a slight underdog against South Carolina.
So, I'd say logically we'd be expected to play roughly a 50/50 game against teams we're most likely to match up with.