I think a lot of that depends on personnel... But sure, he's shown he likes to play 3 guards. Playing 4 guards is a bit different. Mitoglou & Arians played the vast majority of the minutes at the 4 last year... McClinton played some spot minutes there, as well.
Those 3 guys are gone... And there seem to be no replacements for any of them. I don't think Chaundee at the 4 for extended minutes is an answer, though I guess we'll have to see some short stretches of 4 guys under 6'5" on the floor at once. There has to be 1-2 of Sarr/Mitchell/Melo/Washington that can get double-digit minutes a game.
Honestly, the more I think about it, the more I realize I have no idea what we'll do. Hopefully Manning can figure it out.