Somewhat have done it. Drove from Atlanta to LAs Vegas and then back to Chicago for work. Also just drove to Austin from NC when I moved here.
The drive from Atlanta to Vegas is still one of the most memorable things I've ever done. I went Atlanta-Memphis-Oklahoma City-Flagstaff and then the quick 2-3 hour drive to Vegas. The OKC to Flagstaff drive was just breathtaking. Pretty much drove through five different types of terrain in one day. Did it in March, left OKC when it was in the 70's and then 5 hours later I was in a snowstorm on the way to Albuquerque in the Rockies. Stopped off in Laredo b/c its the only real town you hit in the Texas Panhandle (was my first time in TX) and stopped a few other times just to take it all in.
Then on the way out of Vegas, to Chicago, we spent the nights in Denver and Omaha. The two things I remember from that was driving through southern Utah, which was amazing and some
best part imo