As long as your offense doesn't turn the ball over and gift Wake points, Clemson should win pretty easily. Wake's OL is still well below average, and won't have near the success rushing the ball that Pitt did (plus no James Conner). I don't expect Watson to have an easy night, but the Wake secondary can be exploited, given reasonable time to throw. Brad Watson on Mike Williams is not a fun thought.
Unfortunately, gone are the days when Wake had an innovative/misdirection offense, and I imagine Venables is licking his chops at this match-up. Assuming the turnover battle is even or close to it, I'd guess a 31-10 game or something along those lines. It's just impossible to have any confidence in Wake's offense right now (or basically ever).